S. Chennaiah ¹, K. Bhaskarachary ², S. Bapu Rao ², N. Raghuramulu ¹

Affiliations
1 Division of Endocrinology and Metabolism, National Institute of Nutrition, Jamai-Osmania, Hyderabad-500 007, IN
2 Division of Food Chemistry, National Institute of Nutrition, Jamai-Osmania, Hyderabad-500 007, IN

Abstract

Until a few years ago, it was thought that vitamin D₃ and its metabolic derivatives were absent in plant tissues. The observation of plant related calcinosis in certain areas of the world, however, led to the discovery of 1.25 (OH)₂D₃D₃-glycoside in leaves of S.malacoxylon and of vitamin D₃ in T.flavescens. It has been well established that not only animal products contain vitamin D₃ analogues but also plant products have it. Plants particularly those belonging to solanaceae family have been much discussed in these days for their vitamin "D'- like activity. Day blooming Jessamine or Day king i.e. C. diurnum belongs to solanaceae family and has been shown that the leaves of this plant contains vitamin D₃ analogues.

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N. Raghuramulu ¹, H. F. De Luca ²

Affiliations
1 National Institute of Nutrition, Indian Council of Medical Research, Jamai-Osmania P. O., Hyderabad-500007, IN
2 College of Agricultural and Life Sciences, University of Wisconsin, Madison, Wisconsin 53706, US

Abstract

It is very well established that physiologically vitamin D ₃ to function must undergo sequential hydroxylation, first on C-25 in the liver and subsequently on C-1 in the kidney to form 1,25-dihydroxy cholecalciferol (1,25 (OH) ₂ D ₃). This final active metabolite of vitamin D ₃ is then transported from the site of production to the site of action via a specific transport protein.

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